THESIS
2017
xxviii, 130 pages : illustrations (some color) ; 30 cm
Abstract
Fluorescence is a simple and important tool for real-time visualization and
long-term tracking of intracellular structures and processes. Compared to traditional
fluorophores with aggregation-caused quenching (ACQ) effect, aggregation-induced
emission luminogens (AIEgens) have advantages of high brightness, excellent
specificity and superior photostability, which promise their better applications in
biological and medical field.
My thesis research focuses on exploration for bio-applications of some novel
AIEgens. The main part is cell imaging, especially organelles targeting including
mitochondria, lipid droplets and lysosomes. Except for cell imaging, applications in cancer detection and therapy are also developed by taking advantages of the features of
the AIEgen and specific...[
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Fluorescence is a simple and important tool for real-time visualization and
long-term tracking of intracellular structures and processes. Compared to traditional
fluorophores with aggregation-caused quenching (ACQ) effect, aggregation-induced
emission luminogens (AIEgens) have advantages of high brightness, excellent
specificity and superior photostability, which promise their better applications in
biological and medical field.
My thesis research focuses on exploration for bio-applications of some novel
AIEgens. The main part is cell imaging, especially organelles targeting including
mitochondria, lipid droplets and lysosomes. Except for cell imaging, applications in cancer detection and therapy are also developed by taking advantages of the features of
the AIEgen and specific cells. Moreover, some significant intracellular processes such
as organelles migration and autophagy have been successfully visualized and monitored
due to the excellent photostability and biocompatibility of our AIEgens. During my
research, some new AIEgens are designed and developed for applications in the
bio-medical field.
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