THESIS
2017
xliv, 242 pages : illustrations (some color) ; 30 cm
Abstract
To tackle world-challenging problems, luminescent materials have played a vital role
in the promotion of scientific discoveries and technological innovations. Practically,
traditional luminogens often face a problem of aggregation-caused quenching (ACQ),
resulting a reduction or diminishment of luminescence and thus limiting their practical
applications. Circumventing the notorious ACQ effect, luminogens with aggregation-induced
emission characteristics (AIEgens) have become intriguing with a rapid expansion in applications ranging from optoelectronics, chemo/biosensing to bioimaging.
However, to tailor for specific high-tech applications and deepen the mechanistic
understanding of AIEgens, there is a high demand on the developments of novel AIEgens
with easy preparation and fun...[
Read more ]
To tackle world-challenging problems, luminescent materials have played a vital role
in the promotion of scientific discoveries and technological innovations. Practically,
traditional luminogens often face a problem of aggregation-caused quenching (ACQ),
resulting a reduction or diminishment of luminescence and thus limiting their practical
applications. Circumventing the notorious ACQ effect, luminogens with aggregation-induced
emission characteristics (AIEgens) have become intriguing with a rapid expansion in applications ranging from optoelectronics, chemo/biosensing to bioimaging.
However, to tailor for specific high-tech applications and deepen the mechanistic
understanding of AIEgens, there is a high demand on the developments of novel AIEgens
with easy preparation and functionalization. In this thesis, two series of AIEgens were
developed. Their working mechanism and various applications, especially biological
applications, were investigated.
Based on green fluorescence protein chromophore analogues benzylidene-oxazolone,
a series of AIEgens were synthesized with solid quantum yield of up to 50% and emission
wavelength of up to 635 nm. Their working mechanism were carefully deciphered.
Further, through minor modifications, a two-photon AIE bioprobe was developed for
specific lipid droplet imaging in cells and tissues.
Also, we prepared a series of isoquinolinium salts-based AIEgens with high structural
stability via a simple one-pot reaction. With the merits of visible light excitation, large
Stokes shift, high quantum yield, tunable color and sufficient two-photon absorption of
near-infrared light, we found their various applications in mechanochromic rewritable
paper, mitochondrial targeting cell imaging and bacterial imaging. Interestingly, these
molecules exhibited high viscosity-sensitivity and were further utilized as sensors for
extracellular and intracellular microviscosity sensing. Among them, a simple AIEgen was
developed for image-guided two-photon excited photodymanic therapy for precise cancer
treatment.
Post a Comment