THESIS
2018
xxiv, 102, that is, xxv, 105 pages : illustrations (some color) ; 30 cm
Abstract
As an effective approach to overcome the notorious aggregation-caused quenching (ACQ)
problem of traditional fluorescent dyes, materials with aggregation induced emission (AIE)
materials can enhance the fluorescence from luminogens aggregation when their concentrations
increase. With the highly efficient solid-state emission and superior sensitivities, AIE materials
are becoming competitive candidates for high-tech applications and thus attract intense interest
since their first discovery in 2001. Far red/near-infrared (FR/NIR) fluorophores are undergoing
an explosive development in biological application with the superior feature of deeper tissue
penetration, lower auto-fluorescence interference and minimized photo-damaging to biological
structure. Moreover, piezochromic lumine...[
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As an effective approach to overcome the notorious aggregation-caused quenching (ACQ)
problem of traditional fluorescent dyes, materials with aggregation induced emission (AIE)
materials can enhance the fluorescence from luminogens aggregation when their concentrations
increase. With the highly efficient solid-state emission and superior sensitivities, AIE materials
are becoming competitive candidates for high-tech applications and thus attract intense interest
since their first discovery in 2001. Far red/near-infrared (FR/NIR) fluorophores are undergoing
an explosive development in biological application with the superior feature of deeper tissue
penetration, lower auto-fluorescence interference and minimized photo-damaging to biological
structure. Moreover, piezochromic luminescent materials with tunable and reversible emission
in the solid state have potential applications in biotechnology and memory systems. Since both
far red/near-infrared fluorophores and prezochromic luminogens are used in aggregating or
solid state. Therefore, development of highly efficient far red/near-infrared and piezochomic
luminescent materials based on aggregation induced emission (AIE) is very promising to fully
explore their potential and practical applications.
In this thesis, a series of new highly efficient AIE luminogens (AIEgens) have been
designed and synthesized, their emission wavelength range from blue to near-infrared (NIR)
region. Their superior properties and high-tech applications have been investigated.
A novel NIR AIE molecule was designed and synthesized, namely, NZA2TPE, followed
by fabricating nanoparticles through various strategies including both compound-loaded silica
nanoparticles (NPs) and surface modification nanoparticles (NPs). The preparation of
nanoparticles and exploring their specific characteristics replenish the nanomaterials for
purposes of fluorescence imaging and other potential applications.
Far red/near-infrared nanoprobes have been proved as a practically useful tool for
bioimaging with superior features including improved brightness, inertness to their
microenvironment and even more distribution. We reported a simple self-assemble strategy to
prepare nanoparticles by using functional groups DSPE-PEG
2000-Folate to modify the surface
of NZA2TPE. Results indicated that the DSPE-PEG
2000-Folate modified AIE NPs are effective
far red/near-infrared fluorescent bioprobes for cellular imaging with high fluorescence contrast.
Piezochromic AIE luminogens as tunable materials have attracted intense interest in various
fields of applications. 9-(10H)-Acridone and pyridine substituted tetraphenylethene (TPE)
derivatives were synthesized and have proved to possess such properties, which shows an
intriguing color-tuned piezochromic luminescence in response to mechanical stimuli. This
mechanical stimuli responsive system with high contrast luminescence may find practical
applications in the optical recording and sensing.
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