THESIS
2019
xi, 93 pages : illustrations ; 30 cm
Abstract
Cryopreservation of oocytes and embryos plays an important role in the
clinical practice of mammal in vitro fertilization (IVF). Currently, manual
oocyte/embryo vitrification was adopted in IVF clinics worldwide. Because the
inherent drawback of manual operation, practical vitrification suffers by
fluctuated success rate, tedious, time-consuming, and prone to human error.
Microfluidic technology has shown significant breakthroughs in biological
applications such as point-of-care diagnostics, bioterrorism detection, and drug
discovery. In this thesis, we present a microfluidic approach allows the fluid
delivery system to deliver the solution in a programmed and highly control
manner. It successfully resolved the drawbacks of manual vitrification. The
performance of the technolo...[
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Cryopreservation of oocytes and embryos plays an important role in the
clinical practice of mammal in vitro fertilization (IVF). Currently, manual
oocyte/embryo vitrification was adopted in IVF clinics worldwide. Because the
inherent drawback of manual operation, practical vitrification suffers by
fluctuated success rate, tedious, time-consuming, and prone to human error.
Microfluidic technology has shown significant breakthroughs in biological
applications such as point-of-care diagnostics, bioterrorism detection, and drug
discovery. In this thesis, we present a microfluidic approach allows the fluid
delivery system to deliver the solution in a programmed and highly control
manner. It successfully resolved the drawbacks of manual vitrification. The
performance of the technology was verified with mouse embryos. The
vitrification result shows that the success rate of this microfluidic vitrification
chip is 99% compared with 80-90% with traditional manual operation.
Furthermore, this thesis describes a business plan of this microfluidic chip
as an automated human eggs and embryos cryopreservation platform for In-
Vitro fertilization. It also analyses industry, market, the environment of the assisted reproductive technology industry, discusses business model,
development plan, operation plan, and financial projection. We think this
microfluidic technology has great potential to be used as a practical device for
human oocytes and embryos cryopreservation in IVF.
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