THESIS
2020
viii, 59 pages : illustrations ; 30 cm
Abstract
With tremendous 'human mobility,' epidemics are spreading with extraordinary speed across
continents. Accurate testing is one of the most critical measures to prevent epidemics from growing
out of control. However, we are lacking large scale, smart, and accurate testing methods.
We believe that fluorescent microscopy is one of the most suitable techniques for large-scale
testing, and it has enormous market potential. However, the instruments used in fluorescent
microscopy are not only bulky, expensive but also require professionals to control.
We have re-designed a new fluorescent microscope system that is compact, affordable, and easy to
operate. The major re-designed element is the light separation system, where we replace the typical
light separation design by speciall...[
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With tremendous 'human mobility,' epidemics are spreading with extraordinary speed across
continents. Accurate testing is one of the most critical measures to prevent epidemics from growing
out of control. However, we are lacking large scale, smart, and accurate testing methods.
We believe that fluorescent microscopy is one of the most suitable techniques for large-scale
testing, and it has enormous market potential. However, the instruments used in fluorescent
microscopy are not only bulky, expensive but also require professionals to control.
We have re-designed a new fluorescent microscope system that is compact, affordable, and easy to
operate. The major re-designed element is the light separation system, where we replace the typical
light separation design by specially arranged ball lens and Fresnel lens optical structure.
The newly designed fluorescent microscope has multiple advantages. First of all, the light
intensity on the sample is quite high, adequate for at least a 20X magnification objective lens.
With a 4X objective, we have demonstrated resolution of at least 4um.
Secondly, the system is much smaller and more affordable than the conventional filter cube
structure. Manufacturing cost is ten-fold less than the filter cube structure.
Thirdly, our system is versatile and tolerant, unlike the filter cube, which could only separate a
particular pair of wavelengths of light. Our system is compatible with multiple wavelengths of both
illumination and detection with minimal mechanical changes. Moreover, mechanical tolerance is
greatly increased due to fewer optical parts. Lastly, the system is designed for internet control,
which suits the development of 5G internet and enables remote control of the microscope.
A company has been launched for further development and commercialisation of our fluorescent
microscope. A considerable amount of start-up funds have been obtained, and encouraging
collaborations with other companies have also been established. In addition, there has been press
coverage regarding the commercialization of our fluorescent microscope, gaining much attentions
across different communities in the health and food hygiene industry, and also biotechnology fields.
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