THESIS
2021
1 online resource (xiii, 52 pages) : illustrations (chiefly color)
Abstract
Micro-structured flow reactors have a great potential in chemical synthesis due to more efficient heat transfer, better control of mixing, higher yield of desired products, safety when handling reactions involving hazardous substances, and the possibility of automation. Oxygen and water are important analytes in the monitoring of chemical synthesis. They participate in a wide range of processes, which may be desirable or interfering. Among many small molecule sensing methods, the optical chemical sensors are a popular choice, as it features non-invasiveness, full reversibility, precise and accurate measurements, ease of miniaturization, and imaging of the analyte on various scales. However, most oxygen sensors cater to biological studies which emphasise only the physiological range of o...[
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Micro-structured flow reactors have a great potential in chemical synthesis due to more efficient heat transfer, better control of mixing, higher yield of desired products, safety when handling reactions involving hazardous substances, and the possibility of automation. Oxygen and water are important analytes in the monitoring of chemical synthesis. They participate in a wide range of processes, which may be desirable or interfering. Among many small molecule sensing methods, the optical chemical sensors are a popular choice, as it features non-invasiveness, full reversibility, precise and accurate measurements, ease of miniaturization, and imaging of the analyte on various scales. However, most oxygen sensors cater to biological studies which emphasise only the physiological range of oxygen concentration and compatibility with biomolecules or cells. These sensors are often prone to leaching and even dissolution in organic solvents, limiting their use in chemical synthesis. Herein, two optical sensors, one dedicated to trace amounts of oxygen and one dedicated water in a chemical reaction are presented. The sensors were integrated into a microstructured flow reactor, and the sensors enabled real-time and spatially resolved monitoring of oxygen and water.
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