THESIS
2023
1 online resource (xviii, 64 pages) : illustrations (some color)
Abstract
Light is an important factor for life and society. Thus, fluorescent materials have been explored intensively and applied in various areas. However, the development of organic fluorescent materials has been slow since conventional organic light-emitting molecules often emit light in the dissolved or monodisperse state. Once the molecules aggregate to a solid state, the light intensity becomes much weaker or even disappears. This phenomenon is called "aggregation-caused quenching (ACQ). In 2001, our group proposed a new concept termed as “aggregation-induced emission” (AIE). The unique phenomenon intrigued us to explore its mechanism. With detailed investigation of mechanisms, more AIEgens have been designed and synthesized. So far, AIEgens have been widely used in organic light-emitting...[
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Light is an important factor for life and society. Thus, fluorescent materials have been explored intensively and applied in various areas. However, the development of organic fluorescent materials has been slow since conventional organic light-emitting molecules often emit light in the dissolved or monodisperse state. Once the molecules aggregate to a solid state, the light intensity becomes much weaker or even disappears. This phenomenon is called "aggregation-caused quenching (ACQ). In 2001, our group proposed a new concept termed as “aggregation-induced emission” (AIE). The unique phenomenon intrigued us to explore its mechanism. With detailed investigation of mechanisms, more AIEgens have been designed and synthesized. So far, AIEgens have been widely used in organic light-emitting diodes, chemical sensing, biomolecular sensing, bioimaging in vitro/vivo, theranostisc, etc
This thesis mainly focuses on the development of functional AIEgens for information encryption and theranostics. Functional materials with multi-responsive properties and good controllability are highly desired. A novel multiresponsive and controllable AIEgen called CPVCM, which could undergo amination and photorearrangement at the same position was developed. Dip-coated films were fabricated for developing colored images and dynamic QR codes. A multicolor and all-round information encryption system was also built by utilizing the multi-controllability of CPVCM.
The development of aggregation-induced emission (AIE) luminogens for photodynamic therapy (PDT) is of great significance and will bring novel opportunities for bioimaging and non-invasive therapy. A novel AIEgen TBPI was designed and synthesized to precisely target the mitochondria. TBPI displayed robust NIR emission and excelled at ROS generation. TBPI and ISL were utilized to fabricate nanoparticles with great FRET efficiency. ISL+TBPI NPs can be used for PDT and powerfully kill cancer cells.
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