Achieving new developments in DNA nanotechnology by means of DNA self-assembly
by Cheng Jie
M.Phil. Chemical Engineering
x, 81 leaves : ill. ; 30 cm
In this work, we describe the new developments in DNA nanotechnology that we have achieved by means of DNA self‐assembly....[ Read more ]
In this work, we describe the new developments in DNA nanotechnology that we have achieved by means of DNA self‐assembly.
We have designed and developed a novel DNA‐induced solution‐hydrogel transition system to reversibly capture and release proteins. This may provide a promising and potentially convenient tool in drug delivery and protein detection by biosensors.
We have also demonstrated a method of patterning the 1D and 2D arrays of gold nanoparticles (NPs) on DNA self‐assembled scaffolds. 5 nm gold NPs were accurately positioned at the center of each 4×4 tile motif of the DNA scaffold, resulting in 1D or 2D patterns of gold NPs. This precise, controllable scaffolding technology may become a promising tool for nano‐scaled fabrication of electronics and photonic devices.
In addition to gold NPs, we have also fabricated three types of magnetic NPs: FePt NPs, FeAu NPs, and Fe3O4@Au core‐shell NPs. In our future work, we will try to combine these magnetic NPs with DNA nano‐patterning to obtain a nano‐magnetic supermatrix, which may offer potential applications in information storage and microelectronics.