Most infections are initiated at mucosal surfaces, where a highly compartmentalized immunological system resides. The use of mucosal vaccination induces first-line protective immune responses and prevents further spread of the disease. For many years, mucosal immunity and mucosal vaccines have attracted less than their fair share of research and development, considering that most infections have a mucosal portal of entry. But in recent years, increased study of mucosal immune responses has led to a growing interest in both understanding the specific features of mucosal immunity, and developing mucosal vaccines for prevention of mucosal infection. Numerous mucosal antigen delivery and adjuvant systems have been studied. In the present study, we have tried to develop an effective mucosal...[ Read more ]

Most infections are initiated at mucosal surfaces, where a highly compartmentalized immunological system resides. The use of mucosal vaccination induces first-line protective immune responses and prevents further spread of the disease. For many years, mucosal immunity and mucosal vaccines have attracted less than their fair share of research and development, considering that most infections have a mucosal portal of entry. But in recent years, increased study of mucosal immune responses has led to a growing interest in both understanding the specific features of mucosal immunity, and developing mucosal vaccines for prevention of mucosal infection. Numerous mucosal antigen delivery and adjuvant systems have been studied. In the present study, we have tried to develop an effective mucosal vaccine against FMDV antigen in mouse animal model.