THESIS
2013
xiv, 186 p. : ill. (some col.) ; 30 cm
Abstract
A multilevel antimicrobial coating with “release-killing”, “contact-killing” and
“anti-adhesion” properties was prepared from polymer-encapsulated chlorine dioxide (ClO
2)
using water-in-oil-in-water (w/o/w) double emulsion. The applied microencapsulation
technology in this project made a stable double emulsion which protected the active
ingredient from the outside environment, and they acted in a smart way to control the release
rate at different temperatures. Meanwhile, the smart antimicrobial coating was proven to be
safe under normal utilization.
Several kinds of anti-pathogen tests were conducted in this project; the results have proven
that this double-layer emulsion antimicrobial coating provided a long term antimicrobial
efficiency against tested microorganisms, such as...[
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A multilevel antimicrobial coating with “release-killing”, “contact-killing” and
“anti-adhesion” properties was prepared from polymer-encapsulated chlorine dioxide (ClO
2)
using water-in-oil-in-water (w/o/w) double emulsion. The applied microencapsulation
technology in this project made a stable double emulsion which protected the active
ingredient from the outside environment, and they acted in a smart way to control the release
rate at different temperatures. Meanwhile, the smart antimicrobial coating was proven to be
safe under normal utilization.
Several kinds of anti-pathogen tests were conducted in this project; the results have proven
that this double-layer emulsion antimicrobial coating provided a long term antimicrobial
efficiency against tested microorganisms, such as S.aureus, E.coli, P.aeruginosa, B.subtilis
and other infectious pathogens found in hospitals. Research on the antimicrobial mechanism
found that it was correlated with oxidative damage by reactive oxygen species. Antimicrobial
coating has also been proven useful for infection control of spore-forming bacteria and
viruses (eg. H1N1). Finally, a field test in hospital was conducted to mimic the real
application conditions and the antimicrobial results are encouraging. All results demonstrated
that the designed coating has a broad application prospect for infectious disease control in
public places.
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