THESIS
2016
xi, 104 pages : illustrations ; 30 cm
Abstract
Over the last two decades, microfluidics have achieved considerable achievements,
including the development of new fabrication methods and materials, the introduction of
novel theoretical approaches for fluidic modeling and various integrated functional
components. Microfluidic systems possess the potential of manipulating low volume of
liquids in an automatic, multiplexing and highthroughput manner, and they have already been
found widespread applications in material science, bioengineering, system biology and
chemical analysis. Apart from extensive explorations in academic fields, researchers also aim
to develop real-world microfluidic products for point of care devices, portable detection units
and industry-level apparatus.
During my PHD researches, I have focused on develop...[
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Over the last two decades, microfluidics have achieved considerable achievements,
including the development of new fabrication methods and materials, the introduction of
novel theoretical approaches for fluidic modeling and various integrated functional
components. Microfluidic systems possess the potential of manipulating low volume of
liquids in an automatic, multiplexing and highthroughput manner, and they have already been
found widespread applications in material science, bioengineering, system biology and
chemical analysis. Apart from extensive explorations in academic fields, researchers also aim
to develop real-world microfluidic products for point of care devices, portable detection units
and industry-level apparatus.
During my PHD researches, I have focused on developing new fabrication methods for
construction of Teflon and PDMS based microfluidic devices for chemical and biological
analysis: 1) I developed a convenient method for in situ modification of whole-Teflon chip by
polydopamine coating, and demonstrated its applications for immunoassay and long-term cell
culture; 2) I introduced a novel approach-polydopamine assisted electroless plating-to
integrate gold electrodes onto whole-Teflon chip, and showed that this micro electrochemical
chip can perform well both in aqueous and organic solutions; 3) I constructed a multilayer
whole-Teflon chip featured with four inlets and eight outlets, and proved that this platform
can perform bioassay experiments of combinatorial effect studies; 4) I proposed a convenient
strategy to fabricate sub-micrometer channels, and achieved long-term tracking of single
bacterium proliferation.
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