Over the last two decades, microfluidics have achieved considerable achievements, including the development of new fabrication methods and materials, the introduction of novel theoretical approaches for fluidic modeling and various integrated functional components. Microfluidic systems possess the potential of manipulating low volume of liquids in an automatic, multiplexing and highthroughput manner, and they have already been found widespread applications in material science, bioengineering, system biology and chemical analysis. Apart from extensive explorations in academic fields, researchers also aim to develop real-world microfluidic products for point of care devices, portable detection units and industry-level apparatus.

During my PHD researches, I have focused on develop...[ Read more ]

Over the last two decades, microfluidics have achieved considerable achievements, including the development of new fabrication methods and materials, the introduction of novel theoretical approaches for fluidic modeling and various integrated functional components. Microfluidic systems possess the potential of manipulating low volume of liquids in an automatic, multiplexing and highthroughput manner, and they have already been found widespread applications in material science, bioengineering, system biology and chemical analysis. Apart from extensive explorations in academic fields, researchers also aim to develop real-world microfluidic products for point of care devices, portable detection units and industry-level apparatus.

During my PHD researches, I have focused on developing new fabrication methods for construction of Teflon and PDMS based microfluidic devices for chemical and biological analysis: 1) I developed a convenient method for in situ modification of whole-Teflon chip by polydopamine coating, and demonstrated its applications for immunoassay and long-term cell culture; 2) I introduced a novel approach-polydopamine assisted electroless plating-to integrate gold electrodes onto whole-Teflon chip, and showed that this micro electrochemical chip can perform well both in aqueous and organic solutions; 3) I constructed a multilayer whole-Teflon chip featured with four inlets and eight outlets, and proved that this platform can perform bioassay experiments of combinatorial effect studies; 4) I proposed a convenient strategy to fabricate sub-micrometer channels, and achieved long-term tracking of single bacterium proliferation.