THESIS
2016
ix, 44 pages : illustrations (chiefly color) ; 30 cm
Abstract
Nanopores on 2D materials have been identified as one of the best candidates for next generation
DNA sequencing techniques. In this work, computational approach has been adopted
by using Nanoscale Molecular Dynamics (NAMD) simulation to investigate how single-stranded
DNA (ssDNA) interact with solid-state nanopores on hexagonal boron nitride (h-BN)
and monolayer graphene. A base-specific DNA sequencing technique is demonstrated based on
the individual difference in ion current responses for the 4 bases of ssDNA with h-BN and
graphene nanopores. A sequential procedure for DNA sequencing is proposed by making
comparisons between current signals from nanopores on the two membranes to achieve base-specific
detection. The results provide better insights for understanding the dynamics...[
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Nanopores on 2D materials have been identified as one of the best candidates for next generation
DNA sequencing techniques. In this work, computational approach has been adopted
by using Nanoscale Molecular Dynamics (NAMD) simulation to investigate how single-stranded
DNA (ssDNA) interact with solid-state nanopores on hexagonal boron nitride (h-BN)
and monolayer graphene. A base-specific DNA sequencing technique is demonstrated based on
the individual difference in ion current responses for the 4 bases of ssDNA with h-BN and
graphene nanopores. A sequential procedure for DNA sequencing is proposed by making
comparisons between current signals from nanopores on the two membranes to achieve base-specific
detection. The results provide better insights for understanding the dynamics of DNA
translocation event as well as for practical design of DNA sequencing devices.
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