THESIS
2006
xxiv, 207 leaves : ill. (some col.) ; 30 cm
Abstract
In this thesis, we designed and synthesized some novel molecular hydrogelators based on short peptides or amino acids. They showed responses to environmental changes such as pH, temperature, ionic strength or catalytic reactions by enzymes. We divided the thesis into three parts. In part I, we reported the molecular hydrogels response to ligand-receptor interactions. The D-Ala-D-Ala-based hydrogels show responses to the addition of vacomycin. In part II, we talked about enzymatic regulations of molecular hydrogels. We used different enzymes (phosphatase, esterase, MMP-9, beta-lactamase) or enzymatic switch (phosphase/kinase) to control the self-assembly of small molecules in vitro or in vivo. In part III, we introduced the syntheses of novel molecular hydrogelators based on amino acids,...[
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In this thesis, we designed and synthesized some novel molecular hydrogelators based on short peptides or amino acids. They showed responses to environmental changes such as pH, temperature, ionic strength or catalytic reactions by enzymes. We divided the thesis into three parts. In part I, we reported the molecular hydrogels response to ligand-receptor interactions. The D-Ala-D-Ala-based hydrogels show responses to the addition of vacomycin. In part II, we talked about enzymatic regulations of molecular hydrogels. We used different enzymes (phosphatase, esterase, MMP-9, beta-lactamase) or enzymatic switch (phosphase/kinase) to control the self-assembly of small molecules in vitro or in vivo. In part III, we introduced the syntheses of novel molecular hydrogelators based on amino acids, short peptides as well as antibiotic. They formed single or multi-component hydrogels. We also reported the applications of the molecular hydrogels, including the detection of inhibitors of enzyme, removal uranium ions from the wounds on mouse, killing bacteria, etc.
We have used the techniques of SEM, TEM, Rheology, Fluorescent spectra, CD spectra to characterize all the molecular hydrogels and also described the data of pH
gel-sol, T
gel-sol and C
min. in this thesis.
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