THESIS
2013
iv leaves, v-xxii, 199 pages : illustrations (some color) ; 30 cm
Abstract
The calcium (Ca
2+) signals that help regulate skeletal muscle development
and differentiation consist of a complex interaction of excitation-transcription coupling
and excitation-contraction coupling, where both forms of signaling appear to be
necessary to generate anatomically normal and functional muscle. The challenge
when exploring, modulating, and visualizing these Ca
2+ signals, lies in both their
spatial and temporal nature, as well as the variety of Ca
2+ mobilizing agents and
channels/ receptors that come into play. The latest agonist/ receptor pair that has
been reported to be involved in muscle differentiation is nicotinic acid adenine
dinucleotide phosphate (NAADP) and Two-pore channels (TPCs), respectively,
where NAADP has been shown to be the most potent intracellul...[
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The calcium (Ca
2+) signals that help regulate skeletal muscle development
and differentiation consist of a complex interaction of excitation-transcription coupling
and excitation-contraction coupling, where both forms of signaling appear to be
necessary to generate anatomically normal and functional muscle. The challenge
when exploring, modulating, and visualizing these Ca
2+ signals, lies in both their
spatial and temporal nature, as well as the variety of Ca
2+ mobilizing agents and
channels/ receptors that come into play. The latest agonist/ receptor pair that has
been reported to be involved in muscle differentiation is nicotinic acid adenine
dinucleotide phosphate (NAADP) and Two-pore channels (TPCs), respectively,
where NAADP has been shown to be the most potent intracellular Ca
2+ mobilizing
agent described to date. Here I present new data that describes what appears to be
a complex relationship between Ca
2+ released via TPC2, and that via the other two
well-known intracellular Ca
2+ mobilizing receptors, ryanodine receptors (RyRs) and
inositol trisphosphate receptors (IP
3Rs). Furthermore, I show how this interaction
appears to be necessary for normal slow muscle development in the trunk of
segmentation period zebrafish, as well as subsequent contractile activity manifested
as initial spontaneous trunk coiling followed by burst-swimming behavior.
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