ADGRA3, an orphan receptor belonging to adhesion G protein-coupled receptors, is reported to be upregulated in tumors and expressed in spermatogonial progenitor cells. Previous data show that ADGRA3 is also expressed in the brain, especially in the hippocampus. As the hippocampus region is responsible for emotion and memory, we did the related behavior tests of nest building, marble burying and fear conditioning in ADGRA3 KO mice. ADGRA3 KO mice show decreased ability in nest building and marble burying when compared to ADGRA3 WT mice. Synapse plasticity is the foundation of learning and memory, which is the major function of the hippocampus. Besides, many adhesion GPCRs play roles in synaptogenesis. However, ADGRA3 KO mice don’t show altered synapse density in vitro when compa...[ Read more ]

ADGRA3, an orphan receptor belonging to adhesion G protein-coupled receptors, is reported to be upregulated in tumors and expressed in spermatogonial progenitor cells. Previous data show that ADGRA3 is also expressed in the brain, especially in the hippocampus. As the hippocampus region is responsible for emotion and memory, we did the related behavior tests of nest building, marble burying and fear conditioning in ADGRA3 KO mice. ADGRA3 KO mice show decreased ability in nest building and marble burying when compared to ADGRA3 WT mice. Synapse plasticity is the foundation of learning and memory, which is the major function of the hippocampus. Besides, many adhesion GPCRs play roles in synaptogenesis. However, ADGRA3 KO mice don’t show altered synapse density in vitro when compared to ADGRA3 WT mice .