THESIS
2021
1 online resource (xxii, 149 pages) : illustrations (some color)
Abstract
Significant breakthrough in fluorescent materials have been witnessed for advancement of
science and technology in the last century. In biological study, the development of fluorescent
probes with superb brightness, sensitivity, specificity, and biocompatibility is a long-term
pursuit of scientific researchers, which allows for real-time monitoring of biological processes
and on-site detection of biomolecules. While conventional organic fluorophores often
encounter emission quenching in aqueous environment upon aggregation, luminogens with
aggregation-induced emission (AIE) characteristics represent a novel class of material that
overcomes the limitation of conventional fluorophores. Exploitation of high-performance
AIEgens generates unlimited opportunities for a wide range of applicati...[
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Significant breakthrough in fluorescent materials have been witnessed for advancement of
science and technology in the last century. In biological study, the development of fluorescent
probes with superb brightness, sensitivity, specificity, and biocompatibility is a long-term
pursuit of scientific researchers, which allows for real-time monitoring of biological processes
and on-site detection of biomolecules. While conventional organic fluorophores often
encounter emission quenching in aqueous environment upon aggregation, luminogens with
aggregation-induced emission (AIE) characteristics represent a novel class of material that
overcomes the limitation of conventional fluorophores. Exploitation of high-performance
AIEgens generates unlimited opportunities for a wide range of application areas and thus
becomes highly demanded.
Many core structures with molecular rotors have been exploited to meet the demand of
burgeoning AIE research. Herein, the chromophore thiphenylamine (TPA) has recently
emerged as a new class of AIE building block that possesses several notable features, such as
easy modification, high brightness, and marked photostability and biocompatibility. Although
TPA itself is not AIE active, its propeller-shaped structure and electron-rich nature enable it a
perfect constructing unit.
In this thesis, a series of AIE luminogens (AIEgens) built on TPA moiety have been
designed and synthesized for diversified utilization. While much of the initial study was focused
on simply broadening full-color emission AIEgens, the work has further evolved into
development of novel long-wavelength emitting AIEgens and research into their biological
behaviors. These TPA-based AIEgens exhibit outstanding performance in photo-induced
bioimaging and therapy. Some AIEgens with specific subcellular organelle targetability or
elongated wavelength can be readily accessible through structural design.
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